The Prince Edward Theatre is a West End theatre situated on Old Compton Street, just north of Leicester Square, in the City of Westminster, London. The theatre was designed in 1930 by Edward A. Stone, with an interior designed by Marc-Henri Levy and Gaston Laverdet. Named after Prince Edward (at the time Prince of Wales, briefly Edward VIII and later Duke of Windsor), it opened on 3 April 1930 with a performance of the musical Rio Rita.

Other notable events in its opening years included the London debut of famed cabaret artiste Josephine Baker, who performed her famous 'Bananas Dance'.

In 1935, Stone converted the theatre to a dance and cabaret hall, being renamed the "London Casino".

As the London Casino, it was badly damaged and all its windows lost on 10 May 1941, in London's worst air raid of the Second World War. All neighbouring buildings directly across Greek Street were destroyed.

Stage alterations were undertaken by Thomas Braddock in 1942, and that year the building re-opened as the "Queensberry All Services Club"—a club for servicemen where the shows were broadcast on the BBC. After the war, the architects T. and E. Braddock restored the building to theatrical use, becoming the "London Casino" once again — where the 'King of Yiddish Music', Leo Fuld, was a major attraction. The last production before Cinerama took over the building was Wish You Were Here, which included a full-size swimming pool on stage.

The theatre was acquired by EMI, and refurbished at a cost of £150,000. The Cinerama screen was removed and replaced with a conventional one within the proscenium and the 70mm projectors were removed and replaced with a single 35mm projector and non-rewind system. The Casino Theatre continued in use as a cinema showing films, including the remake of King Kong. It also staged occasional theatre productions such as Dean (a musical about James Dean) in 1976, and the following year a Christmas production of Peter Pan with Ron Moody as Captain Hook. The final film run was a revival of Lady Sings the Blues and Mahogany which ended on 8 April 1978. The building was then converted back into a full-time theatre by RHWL Architects and given its original name, reopening with the world première of the musical Evita on 21 June 1978. Further renovations were undertaken by RHWL in 1992–93, increasing the size of the stage, reopening 3 March 1993 with a revival of Crazy for You. The ABBA musical Mamma Mia! premièred here on 6 April 1999, transferring to the Prince of Wales Theatre after a five-year run.

Owned by the Delfont Mackintosh Group, and with a capacity of 1,716, it formerly hosted Mary Poppins until 12 January 2008, before the show toured the UK. Jersey Boys opened on 18 March 2008 and moved to the Piccadilly Theatre in March 2014, A revival of Miss Saigon opened at the Prince Edward Theatre in May 2014.

Disney's production of Aladdin opened in June 2016 at the theatre.